Posted on 13 October 2015
“This discovery demonstrates the tight intertwining between circadian clocks and metabolism, and opens new possibilities for nutritional interventions that modulate the clock’s function. Impaired circadian rhythmicity has been linked to a wide variety of age-related diseases, including cancer, Alzheimer’s disease, Parkinson’s disease, and inflammation.”Diet can influence your rhythm What you eat and when you eat it are both important in determining what your cells will do with the energy. When researchers treated young mice with a drug that blocked metabolism of these polyamine molecules, their rhythm slowed by 11 minutes every day. However, when mice were given increased polyamines their cycle sped up, which was able to reverse the slowing process in older mice. Polyamines and longevity This isn’t the first time polyamines like spermidine have been linked to longevity. They also increase a process called autophagy, which leads to better cell recycling and garbage disposal. There has been evidence that they can increase lifespan, at least in flies. They’re actually found in a variety of foods like soybeans and blue cheese, although at a smaller concentration. Controlling the cycle We’re each born with specific tendencies which affects whether we prefer morning or evening, but there are external elements that can alter our internal rhythms. We know diet plays a role but light exposure, especially blue light, activates daylight sensors which control wakefulness. Spending lots of time before bed gazing at electronic devices, or sleeping in a bright room could potentially be harming your health if they’re a daily activity. We don’t know enough yet about human polyamine usage or the effect of circadian rhythm perturbation in humans, but it could well be another area to explore.
“If they hold true in humans, they will have broad clinical implications. The ability to repair the clock simply through nutritional intervention, namely polyamine supplementation, is exciting and obviously of great clinical potential.”Read more at Medical Daily
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