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Quercetin: An Antioxidant and Synergistic Supplement

Posted on 25 June 2020

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Quercetin is a flavonoid found in fruits and vegetables, and has the advantage of being relatively well studied. On its own, quercetin is a modestly effective supplement. Like other flavonoids, it is an antioxidant, anti-inflammatory molecule, and appears to enhance the immune system. It may also lower blood sugar, reduce blood pressure, protect against cancer and improve lipid profile (lowers LDL cholesterol while increasing HDL cholesterol).

Quercetin structure. Quercetin (3,5,7,3′,4′-pentahydroxyflavone ...
Quercetin structure

Multiple systematic review and meta analyses support the benefits of quercetin: a review of 13 studies found a significant reduction in blood glucose with quercetin supplementation. Another meta analysis suggested that quercetin improved lipid profiles (after 8 weeks of supplementation) and reduced blood pressure.

In addition to these effects, quercetin may also improve the absorption of other supplements. Quercetin inhibits the activity of sulfurotransferases in the intestines and liver – enzymes that metabolise compounds such as resveratrol and limit their availability. Thus, supplementation with quercetin may improve the effectiveness of other supplements.

Among the numerous studies investigating quercetin supplementation in humans, side effects have rarely been found, and those that have are mild in nature. However, there is little data on the effects of quercetin supplementation lasting longer than 12 weeks. Some animal studies also suggest that quercetin may worsen kidney disease.

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    Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis:

    Antidiabetic Effect of Quercetin: A Systematic Review and Meta-Analysis of Animal Studies: DOI: 10.1016/j.fct.2019.01.037

    Quercetin Reduces Markers of Oxidative Stress and Inflammation in Sarcoidosis:

    Effect of Flavonoids on Upper Respiratory Tract Infections and Immune Function: A Systematic Review and Meta-Analysis1,2: doi: 10.3945/an.115.010538

    Quercetin in the Treatment of Dyslipidemia: DOI: 10.5455/medarh.2012.66.87-88

    Safety Aspects of the Use of Quercetin as a Dietary Supplement: DOI: 10.1002/mnfr.201700447

    Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression: doi: 10.1002/jcb.21977

    Inhibition of Human Liver and Duodenum Sulfotransferases by Drugs and Dietary Chemicals: A Review of the Literature: DOI: 10.5414/cpp42488

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