Cancer

Protein and Genome Sequencing brings Personalised Treatments a Step Closer

Posted on 12 May 2019

Researchers have created a publicly available catalogue containing 56,592 different protein mutations present in colon-cancer tissue, which could unearth important biomarkers to help doctors characterise different types of colon cancer.

Source: DOI: 10.1016/j.cell.2019.03.030

The analysis also flagged genes that were unusually active in cancerous tissue, including some that are known to have a role in tumour suppression. A reaction called phosphorylation helped to account for the elevated activity, so the authors suggest that curbing the reaction might return the proteins to their usual anti-cancer function.

Source: nature.com


References

  1. Suhas Vasaikar, Chen Huang et al. Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities. Cell, 177, 4, 5 2019. DOI: 10.1016/j.cell.2019.03.030
  2. https://www.nature.com/articles/d41586-019-01373-6
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