“We identified for the first time a pharmacological approach that reverses all aspects of tau toxicity. Remarkably, the profound protective effects of salsalate were achieved even though it was administered after disease onset, indicating that it may be an effective treatment option.”The Tau protein has not undergone as comprehensive research as its amyloid cousin, so there is no existing drug that targets its build up. After a post-mortem of Alzheimer’s patients, researchers noted that tau acetylation is one of the earliest signs of dementia. The toxic form of tau drives a number of negative processes and neurons fail to combat the onslaught, so many believe it’s time to target tau as well as amyloid.
“Targeting tau acetylation could be a new therapeutic strategy against human tauopathies, like Alzheimer’s disease and FTD. Given that salsalate is a prescription drug with a long-history of a reasonable safety profile, we believe it can have immediate clinical implications.”Because this is a pre-existing drug, there’s hope trials could be comparatively speedy. If salsalate proves to have similar effects on human patients, then it could be an excellent way of fighting dementia progression and even help reverse memory loss. Read more at Neuroscience News
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