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These are just a selection of some of the blood factors that appear to be linked to ageing. It is possible that by removing/blocking factors associated with the ageing process, or by mimicking the activity of the ‘rejuvenating factors’, we may be able rejuvenate tissues in humans and help prevent the onset of age-related diseases. However, while we have seen success in animal models, it remains unclear whether similar effects can be achieved in humans.
References
Circulating plasma factors involved in rejuvenation: https://doi.org/10.18632/aging.103933
Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan: https://doi.org/10.1016/j.celrep.2017.10.057
The exerkine apelin reverses age-associated sarcopenia: https://doi.org/10.1038/s41591-018-0131-6
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis: https://doi.org/10.1038/nm.3898
Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss: https://doi.org/10.18632/aging.103184
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice: https://doi.org/10.1016/j.cmet.2019.05.015
Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells and Reverses Osteoporosis: https://doi.org/10.1634/stemcells.2008-0127
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://doi.org/10.1038/ncomms5082
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