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It therefore appears that scientific advances in genome editing and viral vectors, mounting evidence for the efficacy and safety of gene therapies in humans, as well the loosening of regulation have contributed to the ‘coming of age’ of gene therapy. The immense potential for gene therapy to transform human health as a whole is more realistic than ever, and will hopefully sustain and increase the pace of research and innovation.
References
Adeno-associated virus vector as a platform for gene therapy delivery: https://doi.org/10.1038/s41573-019-0012-9
Gene editing and CRISPR in the clinic: current and future perspectives: https://dx.doi.org/10.1042%2FBSR20200127
The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer: https://www.nature.com/articles/s41392-020-00283-8
History of gene therapy: https://doi.org/10.1016/j.gene.2013.03.137
Gene therapy comes of age: https://science.sciencemag.org/content/359/6372/eaan4672.long
The Return of Gene Therapy: https://www.labiotech.eu/in-depth/gene-therapy-history/
Regulating the gene-therapy revolution: https://www.nature.com/articles/d41586-018-07641-1
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