Posted on 31 August 2020
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or is an essential vitamin that is necessary to support the function of many enzymes.
supplementation may improve longevity and cognition by increasing cellular nicotinamide adenine dinucleotide ( ) levels. is a molecule of interest in the field of ageing research, as decline in levels occurs with age and has been observed in almost all age-related diseases. Preliminary evidence suggests that increasing levels may slow some aspects of the ageing process, but more research is needed to confirm this effect in humans.
is a leading cause of age-related mortality. As we age, fatty deposits accumulate in our arteries ( ), leading to and heart failure. The rate at which this occurs is influenced by the levels of -containing particles in the blood. ( ) accelerates , while ( ) can actually remove lipids from the arterial deposits.
B3 supplementation seems to be very effective at normalising levels in people with low or high . This should make B3 an excellent supplement for protecting against cardiovascular disease, but unfortunately it also reduces the body’s response to , raising blood sugar and cancelling out the benefits with regard to . Supplementation therefore only provides benefits for cardiovascular health if precautions are taken against this effect.
Topical application of vitamin B3 may also improve skin quality and reduce wrinkles slightly.
Numerous studies point towards a reduction in LDL-C and an increase in HDL-C with vitamin B3 supplementation. However, a including 35 760 subjects found no beneficial effect for vitamin B3 in the treatment of , though it may have a role to play in treating patients who are resistant to statins.
One small study reported that vitamin B3 application to the skin improved elasticity and reduced wrinkles.
Examine.com: Vitamin B3 (Niacin): https://examine.com/supplements/vitamin-b3/
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy: DOI: 10.1056/NEJMoa1107579
Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis: DOI: 10.1001/jamanetworkopen.2019.2224
Niacinamide: A B vitamin that improves aging facial skin appearance: DOI: 10.1111/j.1524-4725.2005.31732