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In a recent study, a Stanford research team successfully delivered epigenetic reprogramming , or Yamanaka, factors to human tissue cells. Driving back their epigenetic status into a more youthful state.
Importantly, the team found that if dosed for a short enough time, the cells retained their identity but returned to a younger state, as judged by several measures of cell vigor, including:
Dr. Sebastiano, one of the lead investigators, said the Yamanaka factors appeared to operate in two stages:
The Stanford team extracted aged cartilage cells from patients with osteoarthritis and found that after a low dosage of Yamanaka factors the cells no longer secreted the inflammatory factors that provoke the disease. The team also found that human muscle stem cells, which are impaired in a muscle-wasting disease, could be restored to youth.
Members of the Stanford team have formed a company, Turn Biotechnologies, to develop therapies for osteoarthritis and other diseases. The study is
definitively a step forward in the goal of reversing cellular agingDr. Izpisua Belmonte
The results are novel and represent a significant step toward the goal of reversing cellular aging, and have potential therapeutic implications for aging and aging-related diseases.