Oxford COVID Vaccine Could be Hampered by Adenovirus Immunity

The ChAdOx1 vaccine is a chimpanzee adenovirus modified to produce the Sars-CoV-1 spike protein.
Acquired resistance to adenoviruses may impair the effectiveness of the ChAdOx1
Most of the world has between 50 and 60% immunity to adenoviruses
It may be possible to engineer adenoviruses to hide from the immune system while producing coronavirus proteins
Studies investigating vaccine effectiveness are difficult to compare, as they use different methods to measure immunity.
The ‘ideal’ vaccine would induce neutralising antibodies of multiple subtypes (IgG, IgM, IgA).

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