Infectious Diseases

Oxford COVID Vaccine Could be Hampered by Adenovirus Immunity

30 July 2020

  • The ChAdOx1 vaccine is a chimpanzee adenovirus modified to produce the Sars-CoV-1 spike protein.
  • Acquired resistance to adenoviruses may impair the effectiveness of the ChAdOx1
  • Most of the world has between 50 and 60% immunity to adenoviruses
  • It may be possible to engineer adenoviruses to hide from the immune system while producing coronavirus proteins
  • Studies investigating vaccine effectiveness are difficult to compare, as they use different methods to measure immunity.
  • The ‘ideal’ vaccine would induce neutralising antibodies of multiple subtypes (IgG, IgM, IgA).

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