Clinical trial shows that caloric restriction can reduce cardiovascular and metabolic risk. Even healthy weight adults cutting as little as 300 calories daily significantly improved their heart health markers.
CALERIE was a phase 2 randomised controlled trial in healthy non-obese men and women. Participants were randomly assigned to a 25% calorie restriction diet or an ad libitum control diet.
Calorie restriction caused a persistent and significant reduction of all measured conventional cardiometabolic risk factors e.g. total cholesterol to HDL-cholesterol ratio.
These results suggest that moderate calorie restriction can significantly reduced multiple cardiometabolic risk factors in young and middle-aged healthy individuals, and they offer promise for pronounced long-term population health benefits.