‘Measuring Biological Aging in Human: The Quest’ is a review inspired by two pillars of the aging science literature; the hallmarks of aging and the pillars of aging. As well as looking at the most recent research in and around the gerontology community, this review focuses on translating the fundamental knowledge of the biological mechanisms of aging with into a clinical aspect.
Current research focuses on measuring the pace of aging to identify individuals who are “aging faster” to test and develop interventions that could prevent or delay the progression of multimorbidity and disability with aging. Understanding how the underlying biological mechanisms of aging connect to and impact longitudinal changes in health trajectories offers a unique opportunity to identify resilience mechanisms, their dynamic changes, and their impact on stress responses. Harnessing how to evoke and control resilience mechanisms in individuals with successful aging could lead to writing a new chapter in human medicine.Luigi Ferrucci, Marta Gonzalez-Freire, et al.