Longevity

Longevity Daily: 5th August, 2020

Posted on 5 August 2020

Everyday our team of researchers in Oxford are inundated with scientific, and medical research articles that have the potential to improve health, wellbeing, and longevity. In this blog we highlight a few of them that caught our attention today.

red moon during night time
Photo by Pedro Figueras on Pexels.com
  1. Being out in the sunshine is often thought to improve ones mood. Therefore researchers think that Vitamin D supplementation could improve depression in people.
  2. Your gut microbiota is unique, and can have significant impact on your health and wellbeing. Now we are learning that harming the microbiome during infancy can have long lasting impacts.
    • In a new study from Singapore researchers showed that use of antibiotics in infancy can raise the risk of obesity in early childhood, with the boys being slightly more vulnerable.
    • Recurrening use of antibiotics can disrupt the development of infant gut microbiota and serve as a potential mechanism for linking antibiotic exposure with later life obesity, and accumulation of fat.

  3. Identifying targets to extend lifespan in animals is a stepping stone to developing therapies that may enhance human longevity.
    • Cdc42 is a regulatory enzyme found to be elevated in old mice, and its overexpression results in premature ageing and reduced lifespan.
    • This study suggests that inhibition of Cdc42 significantly extends average lifespan in aged mice. Treated animals also displayed youthful levels inflammatory mediators and DNA methylation levels corresponding to a younger epigenetic clock.

  4. Wellbeing during childhood and adolescence plays a major role in your health during later life. Therefore there is a possibility that it can impact aging processes.
    • New systematic review study has shown that traumatic or violent experiences in childhood accelerate cellular aging, measured by leukocyte telomere length and DNA methylation age, and early pubertal development.
    • Interestingly, exposure to deprivation (e.g. neglect, institutional rearing) and low socio-economical status do not share the same effect with exposure to violence, which shows that different experiences influence different aspects of biological aging.


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