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Longevity Briefs: SynergyAge – A new publicly available database to help solve aging

Posted on 29 October 2020

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Longevity briefs provides a short summary of a novel research, medicine, or technology that caught the attention of our researchers in Oxford, due to its potential to improve our health, wellbeing, and longevity.

Why is this research important: Longevity genes play a critical role in how long we stay healthy for. Understanding how these longevity genes interact with each other is an extremely complex, yet absolutely fundamental aspect of uncovering the mysteries of the aging process.

What did the researchers do: To help understand these interactions, a group of longevity scientists led by Professor Robi Tacutu, from the Institute of Biochemistry of the Romanian Academy, have curated SynergyAge.

SynergyAge is a database containing genetic and lifespan data for animal models obtained through multiple longevity-modulating interventions.

SynergyAge includes data from three of the most commonly used animal models for lifespan studies. Source:

Key takeaway(s) from this research: The authors mention that…

With the creation of SynergyAge, we aimed to encourage and support the investigation of the cumulative effects of different gene interventions on lifespan, by providing the scientific community with a “one-stop” web platform to access, compare and analyze lifespan synergisms or antagonisms

Source: SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes.

This tool can be particularly useful for researchers when designing lab experiments in which multiple genetic interventions are required.


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