Longevity

Longevity Briefs: Reducing Aging, and Compressing Morbidity with Alphaketogluterate – Dr. Brian Kennedy

6 April 2021

Longevity briefs provides a short summary of novel research in biology, medicine, or biotechnology that caught the attention of our researchers in Oxford, due to its potential to improve our health, wellbeing, and longevity.

Dr. Kennedy is currently a Professor of Biochemistry and Physiology at National University Singapore and Director of the Centre for Healthy Ageing in the National University Health System. He also serves as a Co-Editor-In-Chief at Aging Cell. In this short extract from Chris’s discussion with Dr. Kennedy, he talks about alphaketogluterate and how it slowed down the biological ageing of mice.

In the full talk, Dr. Brian Kennedy discusses his personal long-term health journey, his current work in Singapore and how they’re becoming ‘healthy-ageing’ progressive nation, and how he plans to improve human health and longevity.

Dr. Kennedy is also the Chief Scientific Officer of Ponce De Leon Health. Ponce De Leon Health is a longevity company focused on reversing epigenetic aging. In 2020, they announced the results of pilot research suggesting that their Rejuvant® LifeTabs®, reduced the biological age of customers by an average of 8.5 years. The biological age was assessed by way of a DNA biomarker test that measures DNA methylation. Of the subjects in the analysis, two-thirds showed a statistically significant reduction in biological age. The analysis was based on data from subjects who had taken Rejuvant LifeTabs for a period of four to six months.

LifeTabs® is a formulation containing LifeAKG™, a proprietary form of Calcium Alpha-Ketoglutarate (Ca-AKG), designed to ensure optimal delivery for use by the body’s cells. Rejuvant™ LifeTabs™ is a patent-pending combination of GRAS ingredients developed in collaboration with Dr. Brian Kennedy of the Buck Institute for Research on Aging, to modulate pathways associated with healthy aging, including DNA de-methylation, potentially decreasing biological age.

Watch the full conversation talk with Brian here.


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