Posted on 10 May 2019
The first therapeutic use of engineered phages (viruses that infect bacteria) to treat human mycobacterial infection. A patient had complete remission after 6 weeks of treatment with these engineered phages. This presents a plausible alternative to treatment with antibiotics.
A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward geneticsRebekah M. Dedrick et al. (2019)