Posted on 8 December 2019
Researchers at the Broad Institute, in America, have developed a new tool to classify bacterial strains with 94-99% accuracy called Genotypic and Phenotypic AST through RNA detection, otherwise known as GoPhAST-R. This approach improves on current growth-based assays in the presence of various antibiotics, which take several days to obtain results and then a clinical decision.
Furthermore, this technique detects distinct patterns of mRNA expression which can be used to distinguish drug-sensitive from drug-resistant microbes. This can be used to rapidly determine antibiotic susceptibility of pathogens in a sample within 4 hours and can be applied to any bacterial infection and antibiotic.
The ability to quickly and accurately identify the best antibiotic would greatly improve the care of patients with infection, while ensuring that our arsenal of antibiotics is deployed intelligently and efficientlyDeborah Hung, the Broad Institute. Accessed via: https://www.broadinstitute.org/news/new-diagnostic-approach-rapidly-identifies-right-antibiotics
Clinical use of GoPhAST-R has amazing potentials for improving diagnosis and treatment of infectious diseases as well as preventing the spread of antimicrobial resistance and the emergence of super-bugs.