“That protein, which has an ortholog in humans, is a major decider of what happens to fat inside intestinal cells. If you reduce the production of these lipoproteins you allow the fat to be reused in different ways”From research on the similar protein in nematode worms, VIT seems to inhibit a process called lipophagy. This is essentially the breakdown of fats, which allows them to be used for other purposes. Greater lipophagy and autophagy, a cell’s ‘self eating’ capacity to recycle and re-use old or damaged materials, appears to be protective – preventing material hanging around long enough to accumulate damage. In the lab, blocking VIT had no benefits if autophagy was inhibited at the same time, so it appears one of the main protective effects of inhibiting VIT is indeed boosting the cell’s disposal and recycling abilities. This is potentially the same in humans, as ApoB plays a very similar role.
“Altogether our data supports a model in which lipoprotein biogenesis prevents life span extension by distributing lipids away from the intestine, and by negatively regulating the induction of autophagy-related and lysosomal lipase genes, thereby challenging the animal’s ability to maintain lipid homeostasis and somatic maintenance”A link to calorie restriction The benefits of calorie restriction are less clearly established in humans, but it does have protective effect on cardiovascular disease risk. One reason for this is perhaps that CR reduces production of ApoB and allows cells across the body to keep up protective levels of recycling. More research on ApoB may reveal ways to mimic beneficial effects, with less challenging dietary requirements. Read more at MedicalXpress
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