In a study done at Salk Institute, scientists have demonstrated more clearly the cellular effects of caloric restriction as related to aging .
We already knew that calorie restriction increases life span, but now we’ve shown all the changes that occur at a single-cell level to cause that,” stated senior study author Juan Carlos Izpisua Belmonte, the Roger Guillemin Chair holder at the Salk Institute for Biological Studies.
The primary discovery in the current study is that the increase in the inflammatory response during aging could be systematically repressed by caloric restriction,” said Jing Qu, a corresponding author and professor at the Chinese Academy of Sciences.
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Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging: https://www.cell.com/cell/pdf/S0092-8674(20)30152-5.pdf
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