Supplements

Alpha-Lipoic Acid: an Anti-ageing supplement?

Posted on 27 November 2019

Alpha-Lipoic Acid (ALA) is a mitochondrial compound that is intrinsically involved in energy metabolism. It is synthesised in the body and can be consumed through eating meat. It is also present in small doses in some fruits and vegetables. [1]

As a supplement, it has been shown to protect against:

– heart disease

– liver disease

– diabetes

– neurodegeneration

via its anti-oxidation and anti-inflammatory characteristics . It has also been shown to reverse the oxidant damage of ageing.

In a meta-analysis looking at its beneficial affects on alleviating symptoms of diabetic neuropathy it was concluded that ALA is a legitimate treatment option. However, the mechanism of action has not been deciphered as of yet. [2]

There is also a wealth of evidence demonstrating the beneficial effects of ALA supplementation and the reduction of oxidation biomarkers. [1]

When it comes to alpha-lipoic acid as an anti-ageing supplement, a study in rats has shown a 30% increase in lifespan after 12 months of supplementation,. However, these effects have not been replicated in humans as of yet. [3]


References

  1. https://examine.com/supplements/alpha-lipoic-acid/
  2. Foster, T. S. (2007). Efficacy and Safety of α-Lipoic Acid Supplementation in the Treatment of Symptomatic Diabetic Neuropathy. The Diabetes Educator, 33(1), 111–117. https://doi.org/10.1177/0145721706297450
  3. Merry, B. J. et al. (2008). Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span. Mechanisms of Ageing and Development Volume 129, Issue 6. DOI: 10.1016/j.mad.2008.04.004
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