Receive our unique vitiligo formula, completely FREE of charge!


Ageing, Metformin, and You

Posted on 28 January 2020

Getting your Trinity Audio player ready...

Metformin is a relatively inexpensive drug, commonly prescribed for the treatment of type 2 diabetes. It works by modifying the activity of pathways regulated by insulin, but interestingly, also modulates processes that are thought to underly ageing, including senescence, inflammation, mitochondrial function, epigenetic modification and telomere length. As such, there has been mounting interest in its potential anti-ageing properties.

Image result for metformin anti aging

Metformin can have a significant effect on ageing in animal models, with one study demonstrating a 40% increase in lifespan in worms. However, results from such research have been mixed: the effects of metformin are less pronounced in mice, and seemingly non-existent in fruit flies.

But what of the effects of metformin in humans? Research has suggested that metformin can slow cognitive decline, and lower risk of cancer. However, this does not mean that non-diabetics should be taking metformin. The majority of the aforementioned research is conducted in diabetics or prediabetics, and there is not enough data on the effects of metformin in healthy individuals to draw any firm conclusions.

Moreover, exercise and caloric restriction act through similar pathways to metformin, and offer greater health benefits. One study found that exercise was nearly twice as effective as metformin when it came to preventing progression of prediabetes, and there is also evidence that metformin actually counteracts some of the benefits of physical activity.

There is great appeal in a miracle pill that will slow ageing without any effort on our part. For the foreseeable future however, exercise, healthy eating, and abstinence from smoking are likely to remain the most potent pills available!

Never Miss a Breakthrough!

Sign up for our newletter and get the latest breakthroughs direct to your inbox.

    Featured in This Post

    Never Miss a Breakthrough!

    Sign up for our newletter and get the latest breakthroughs direct to your inbox.

      Copyright © Gowing Life Limited, 2024 • All rights reserved • Registered in England & Wales No. 11774353 • Registered office: Ivy Business Centre, Crown Street, Manchester, M35 9BG.