Posted on 13 September 2015
“Many of us know from our own experiences that muscle weakness and atrophy are big problems as we become older”What can we do about it? Researchers also identified two molecules that dramatically reduce this age-related decline in mice: ursolic acid from apple peels, and tomatidine, present in green tomatoes. When elderly mice were fed either of these compounds, muscle mass was increased by 10% and muscle strength by 30% – essentially restoring their muscles to a youthful state.
“Based on these results, ursolic acid and tomatidine appear to have a lot of potential as tools for dealing with muscle weakness and atrophy during aging. We also thought we might be able to use ursolic acid and tomatidine as tools to find a root cause of muscle weakness and atrophy during aging.”As they explored further, the team found that both compounds switch off genes that ATF4 activates. When they then engineered mice without ATF4, they actually proved resistant to muscular aging.
“By reducing ATF4 activity, ursolic acid and tomatidine allow skeletal muscle to recover from effects of aging”Read more at Medicalxpress
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